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The story involves human mutations called "Diclonius", who grow horns on their heads and possess telekinetic powers, in the form of invisible "arms" called vectors. The tendency for violence among Diclonii varies among characters. Certain scientists contain them in a Facility in cells, where they are subject to inhumane experiments to test their abilities or where they await execution for being too dangerous. An infectious virus is also associated with the mutation. This virus is spread through non-lethal contact with the vectors of a diclonius. The main non-mutant character in the story is Kouta, who ends up becoming increasingly involved with these dicloniuses, as they seek refuge from the scientists. The main diclonius character is Lucy/Nyuu, a killer whose alter ego is a hapless and very cute child whose vocabulary and intelligence are quite limited.
The summary from AT-Translations: Ikuto Touhohin just had a last fight with his old man, one that led him to make a rash decision to run away from home. He boards a ship, deciding to take a vacation, but the ship is suddenly hit by a huge storm--one that sends Ikuto overboard! When he regains consciousness, he realizes he is still alive…on some island. An isolated island. An isolated island with nothing but girls. Stranded on an island with only girls, no electricity, gas, radio, television…like he has gone back over a 100 years in history.